CIC-LMNA Fusion FISH Probe
The CIC-LMNA Fusion FISH Probe is used to confirm a fusion of the CIC and LMNA genes. The fusion of the CIC and LMNA genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CIC-LMNA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-RERE | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-REOR | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-REGO | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-REGR | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-OROR | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-GORE | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-GROR | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| CIC-LMNA-20-AQAQ | 20 (40 μL) | 200 μL |
|
LMNA Gene Summary
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
Gene Name: Lamin A/C
Chromosome: CHR1: 156084460 -156109878
Locus: 1q22
CIC Gene Summary
The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Gene Name: Capicua Transcriptional Repressor
Chromosome: CHR19: 42788816 -42799949
Locus: 19q13.2
Gene Diseases
The CIC LMNA Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|