CIC-KLK11 Fusion FISH Probe
The CIC-KLK11 Fusion FISH Probe is used to confirm a fusion of the CIC and KLK11 genes. The fusion of the CIC and KLK11 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CIC-KLK11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-RERE | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-REOR | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-REGO | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-REGR | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-REAQ | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-ORRE | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-OROR | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-ORGO | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-ORAQ | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-GORE | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-GOOR | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-GOGO | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-GOGR | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-GOAQ | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-GRRE | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-GROR | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-GRGO | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-GRGR | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-GRAQ | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-AQRE | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-AQOR | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-AQGO | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-AQGR | 20 (40 μL) | 200 μL |
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| CIC-KLK11-20-AQAQ | 20 (40 μL) | 200 μL |
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KLK11 Gene Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]
Gene Name: Kallikrein Related Peptidase 11
Chromosome: CHR19: 51525486 -51531290
Locus: 19q13.41
CIC Gene Summary
The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Gene Name: Capicua Transcriptional Repressor
Chromosome: CHR19: 42788816 -42799949
Locus: 19q13.2
Gene Diseases
The CIC KLK11 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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