CIC-DLK1 Fusion FISH Probe
The CIC-DLK1 Fusion FISH Probe is used to confirm a fusion of the CIC and DLK1 genes. The fusion of the CIC and DLK1 genes has been associated with Pheochromocytoma And Paraganglioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CIC-DLK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-RERE | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-REOR | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-REGO | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-REGR | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-REAQ | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-ORRE | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-OROR | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-ORGO | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-GORE | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-GOOR | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-GOGO | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-GOGR | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-GRRE | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-GROR | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-GRGO | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-GRGR | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-AQRE | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-AQOR | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-AQGO | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-AQGR | 20 (40 μL) | 200 μL |
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| CIC-DLK1-20-AQAQ | 20 (40 μL) | 200 μL |
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DLK1 Gene Summary
This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015]
Gene Name: Delta Like Non-canonical Notch Ligand 1
Chromosome: CHR14: 101193201 -101201467
Locus: 14q32.2
CIC Gene Summary
The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Gene Name: Capicua Transcriptional Repressor
Chromosome: CHR19: 42788816 -42799949
Locus: 19q13.2
Gene Diseases
The CIC DLK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Pheochromocytoma And Paraganglioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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