CHSY1-PCSK6 Fusion FISH Probe
The CHSY1-PCSK6 Fusion FISH Probe is used to confirm a fusion of the CHSY1 and PCSK6 genes. The fusion of the CHSY1 and PCSK6 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHSY1-PCSK6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-RERE | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-REOR | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-REGO | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-REGR | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-REAQ | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-ORRE | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-OROR | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-ORGO | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-GORE | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-GOOR | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-GOGO | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-GOGR | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-GRRE | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-GROR | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-GRGO | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-GRGR | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-AQRE | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-AQOR | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-AQGO | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-AQGR | 20 (40 μL) | 200 μL |
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| CHSY1-PCSK6-20-AQAQ | 20 (40 μL) | 200 μL |
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PCSK6 Gene Summary
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]
Gene Name: Proprotein Convertase Subtilisin/kexin Type 6
Chromosome: CHR15: 101844132 -102030187
Locus: 15q26.3
CHSY1 Gene Summary
This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dual glucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation and morphogenesis. Decreased expression of this gene may play a role in colorectal cancer, and mutations in this gene are a cause of temtamy preaxial brachydactyly syndrome. [provided by RefSeq, Dec 2011]
Gene Name: Chondroitin Sulfate Synthase 1
Chromosome: CHR15: 101715927 -101792137
Locus: 15q26.3
Gene Diseases
The CHSY1 PCSK6 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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