CHST11-TXNRD1 Fusion FISH Probe
The CHST11-TXNRD1 Fusion FISH Probe is used to confirm a fusion of the CHST11 and TXNRD1 genes. The fusion of the CHST11 and TXNRD1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHST11-TXNRD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-RERE | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-REOR | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-REGO | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-REGR | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-REAQ | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-ORRE | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-OROR | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-ORGO | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-GORE | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-GOOR | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-GOGO | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-GOGR | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-GRRE | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-GROR | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-GRGO | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-GRGR | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-AQRE | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-AQOR | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-AQGO | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-AQGR | 20 (40 μL) | 200 μL |
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| CHST11-TXNRD1-20-AQAQ | 20 (40 μL) | 200 μL |
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TXNRD1 Gene Summary
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017]
Gene Name: Thioredoxin Reductase 1
Chromosome: CHR12: 104609558 -104744062
Locus: 12q23.3
CHST11 Gene Summary
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Name: Carbohydrate Sulfotransferase 11
Chromosome: CHR12: 104850691 -105155792
Locus: 12q23.3
Gene Diseases
The CHST11 TXNRD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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