CHST11-ATP1B4 Fusion FISH Probe
The CHST11-ATP1B4 Fusion FISH Probe is used to confirm a fusion of the CHST11 and ATP1B4 genes. The fusion of the CHST11 and ATP1B4 genes has been associated with Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHST11-ATP1B4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-RERE | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-REOR | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-REGO | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-REGR | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-REAQ | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-ORRE | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-OROR | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-ORGO | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-GORE | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-GOOR | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-GOGO | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-GOGR | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-GRRE | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-GROR | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-GRGO | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-GRGR | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-AQRE | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-AQOR | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-AQGO | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-AQGR | 20 (40 μL) | 200 μL |
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| CHST11-ATP1B4-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP1B4 Gene Summary
This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Name: ATPase Na+/K+ Transporting Family Member Beta 4
Chromosome: CHRX: 119495939 -119517104
Locus: Xq24
CHST11 Gene Summary
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Name: Carbohydrate Sulfotransferase 11
Chromosome: CHR12: 104850691 -105155792
Locus: 12q23.3
Gene Diseases
The CHST11 ATP1B4 Fusion has been associated with the following diseases:
| Disease Name |
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| Acute Myeloid Leukemia |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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