CHRM3-SYT14 Fusion FISH Probe
The CHRM3-SYT14 Fusion FISH Probe is used to confirm a fusion of the CHRM3 and SYT14 genes. The fusion of the CHRM3 and SYT14 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CHRM3-SYT14-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-RERE | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-REOR | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-REGO | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-REGR | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-OROR | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-GORE | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-GROR | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| CHRM3-SYT14-20-AQAQ | 20 (40 μL) | 200 μL |
|
CHRM3 Gene Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
Gene Name: Cholinergic Receptor Muscarinic 3
Chromosome: CHR1: 239792372 -240072717
Locus: 1q43
SYT14 Gene Summary
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate membrane trafficking in synaptic transmission. The encoded protein is a calcium-independent synaptotagmin. Mutations in this gene are a cause of autosomal recessive spinocerebellar ataxia-11 (SCAR11), and a t(1;3) translocation of this gene has been associated with neurodevelopmental abnormalities. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Dec 2011]
Gene Name: Synaptotagmin 14
Chromosome: CHR1: 210111537 -210337633
Locus: 1q32.2
Gene Diseases
The CHRM3 SYT14 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|