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CHRM3-CASQ1 Fusion FISH Probe

The CHRM3-CASQ1 Fusion FISH Probe is used to confirm a fusion of the CHRM3 and CASQ1 genes. The fusion of the CHRM3 and CASQ1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CHRM3-CASQ1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CHRM3-CASQ1-20-RERE 20 (40 μL) 200 μL
CHRM3-CASQ1-20-REOR 20 (40 μL) 200 μL
CHRM3-CASQ1-20-REGO 20 (40 μL) 200 μL
CHRM3-CASQ1-20-REGR 20 (40 μL) 200 μL
CHRM3-CASQ1-20-REAQ 20 (40 μL) 200 μL
CHRM3-CASQ1-20-ORRE 20 (40 μL) 200 μL
CHRM3-CASQ1-20-OROR 20 (40 μL) 200 μL
CHRM3-CASQ1-20-ORGO 20 (40 μL) 200 μL
CHRM3-CASQ1-20-ORAQ 20 (40 μL) 200 μL
CHRM3-CASQ1-20-GORE 20 (40 μL) 200 μL
CHRM3-CASQ1-20-GOOR 20 (40 μL) 200 μL
CHRM3-CASQ1-20-GOGO 20 (40 μL) 200 μL
CHRM3-CASQ1-20-GOGR 20 (40 μL) 200 μL
CHRM3-CASQ1-20-GOAQ 20 (40 μL) 200 μL
CHRM3-CASQ1-20-GRRE 20 (40 μL) 200 μL
CHRM3-CASQ1-20-GROR 20 (40 μL) 200 μL
CHRM3-CASQ1-20-GRGO 20 (40 μL) 200 μL
CHRM3-CASQ1-20-GRGR 20 (40 μL) 200 μL
CHRM3-CASQ1-20-GRAQ 20 (40 μL) 200 μL
CHRM3-CASQ1-20-AQRE 20 (40 μL) 200 μL
CHRM3-CASQ1-20-AQOR 20 (40 μL) 200 μL
CHRM3-CASQ1-20-AQGO 20 (40 μL) 200 μL
CHRM3-CASQ1-20-AQGR 20 (40 μL) 200 μL
CHRM3-CASQ1-20-AQAQ 20 (40 μL) 200 μL

CASQ1 Gene Summary

This gene encodes the skeletal muscle specific member of the calsequestrin protein family. Calsequestrin functions as a luminal sarcoplasmic reticulum calcium sensor in both cardiac and skeletal muscle cells. This protein, also known as calmitine, functions as a calcium regulator in the mitochondria of skeletal muscle. This protein is absent in patients with Duchenne and Becker types of muscular dystrophy. [provided by RefSeq, Jun 2013]

Gene Name: Calsequestrin 1

Chromosome: CHR1: 160160284 -160171676

Locus: 1q23.2

CHRM3 Gene Summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]

Gene Name: Cholinergic Receptor Muscarinic 3

Chromosome: CHR1: 239792372 -240072717

Locus: 1q43

Gene Diseases

The CHRM3 CASQ1 Fusion has been associated with the following diseases:

Disease Name
Lung Squamous Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.