CHRM3-CASQ1 Fusion FISH Probe
The CHRM3-CASQ1 Fusion FISH Probe is used to confirm a fusion of the CHRM3 and CASQ1 genes. The fusion of the CHRM3 and CASQ1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHRM3-CASQ1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-RERE | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-REOR | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-REGO | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-REGR | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-REAQ | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-ORRE | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-OROR | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-ORGO | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-GORE | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-GOOR | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-GOGO | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-GOGR | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-GRRE | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-GROR | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-GRGO | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-GRGR | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-AQRE | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-AQOR | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-AQGO | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-AQGR | 20 (40 μL) | 200 μL |
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| CHRM3-CASQ1-20-AQAQ | 20 (40 μL) | 200 μL |
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CASQ1 Gene Summary
This gene encodes the skeletal muscle specific member of the calsequestrin protein family. Calsequestrin functions as a luminal sarcoplasmic reticulum calcium sensor in both cardiac and skeletal muscle cells. This protein, also known as calmitine, functions as a calcium regulator in the mitochondria of skeletal muscle. This protein is absent in patients with Duchenne and Becker types of muscular dystrophy. [provided by RefSeq, Jun 2013]
Gene Name: Calsequestrin 1
Chromosome: CHR1: 160160284 -160171676
Locus: 1q23.2
CHRM3 Gene Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
Gene Name: Cholinergic Receptor Muscarinic 3
Chromosome: CHR1: 239792372 -240072717
Locus: 1q43
Gene Diseases
The CHRM3 CASQ1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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