CHMP4B-CBFA2T2 Fusion FISH Probe
The CHMP4B-CBFA2T2 Fusion FISH Probe is used to confirm a fusion of the CHMP4B and CBFA2T2 genes. The fusion of the CHMP4B and CBFA2T2 genes has been associated with Breast Invasive Carcinoma, Stomach Adenocarcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHMP4B-CBFA2T2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-RERE | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-REOR | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-REGO | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-REGR | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-REAQ | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-ORRE | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-OROR | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-ORGO | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-GORE | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-GOOR | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-GOGO | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-GOGR | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-GRRE | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-GROR | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-GRGO | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-GRGR | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-AQRE | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-AQOR | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-AQGO | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-AQGR | 20 (40 μL) | 200 μL |
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| CHMP4B-CBFA2T2-20-AQAQ | 20 (40 μL) | 200 μL |
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CBFA2T2 Gene Summary
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
Gene Name: CBFA2/RUNX1 Translocation Partner 2
Chromosome: CHR20: 32077927 -32237837
Locus: 20q11.21-q11.22
CHMP4B Gene Summary
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]
Gene Name: Charged Multivesicular Body Protein 4B
Chromosome: CHR20: 32399109 -32442173
Locus: 20q11.22
Gene Diseases
The CHMP4B CBFA2T2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Stomach Adenocarcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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