CHM-KLHL4 Fusion FISH Probe
The CHM-KLHL4 Fusion FISH Probe is used to confirm a fusion of the CHM and KLHL4 genes. The fusion of the CHM and KLHL4 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHM-KLHL4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-RERE | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-REOR | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-REGO | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-REGR | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-REAQ | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-ORRE | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-OROR | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-ORGO | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-GORE | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-GOOR | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-GOGO | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-GOGR | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-GRRE | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-GROR | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-GRGO | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-GRGR | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-AQRE | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-AQOR | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-AQGO | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-AQGR | 20 (40 μL) | 200 μL |
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| CHM-KLHL4-20-AQAQ | 20 (40 μL) | 200 μL |
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CHM Gene Summary
This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
Gene Name: CHM, Rab Escort Protein 1
Chromosome: CHRX: 85116184 -85302566
Locus: Xq21.2
KLHL4 Gene Summary
This gene encodes a member of the kelch family of proteins, which are characterized by kelch repeat motifs and a POZ/BTB protein-binding domain. It is thought that kelch repeats are actin binding domains. However, the specific function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Kelch Like Family Member 4
Chromosome: CHRX: 86772714 -86925050
Locus: Xq21.31
Gene Diseases
The CHM KLHL4 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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