CHM-KCNIP4 Fusion FISH Probe
The CHM-KCNIP4 Fusion FISH Probe is used to confirm a fusion of the CHM and KCNIP4 genes. The fusion of the CHM and KCNIP4 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHM-KCNIP4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-RERE | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-REOR | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-REGO | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-REGR | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-REAQ | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-ORRE | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-OROR | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-ORGO | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-GORE | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-GOOR | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-GOGO | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-GOGR | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-GRRE | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-GROR | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-GRGO | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-GRGR | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-AQRE | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-AQOR | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-AQGO | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-AQGR | 20 (40 μL) | 200 μL |
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| CHM-KCNIP4-20-AQAQ | 20 (40 μL) | 200 μL |
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CHM Gene Summary
This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
Gene Name: CHM, Rab Escort Protein 1
Chromosome: CHRX: 85116184 -85302566
Locus: Xq21.2
KCNIP4 Gene Summary
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Potassium Voltage-gated Channel Interacting Protein 4
Chromosome: CHR4: 20730238 -21950374
Locus: 4p15.31-p15.2
Gene Diseases
The CHM KCNIP4 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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