CHI3L1-UTRN Fusion FISH Probe
The CHI3L1-UTRN Fusion FISH Probe is used to confirm a fusion of the CHI3L1 and UTRN genes. The fusion of the CHI3L1 and UTRN genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHI3L1-UTRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-RERE | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-REOR | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-REGO | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-REGR | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-REAQ | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-ORRE | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-OROR | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-ORGO | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-GORE | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-GOOR | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-GOGO | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-GOGR | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-GRRE | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-GROR | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-GRGO | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-GRGR | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-AQRE | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-AQOR | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-AQGO | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-AQGR | 20 (40 μL) | 200 μL |
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| CHI3L1-UTRN-20-AQAQ | 20 (40 μL) | 200 μL |
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CHI3L1 Gene Summary
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]
Gene Name: Chitinase 3 Like 1
Chromosome: CHR1: 203148058 -203155922
Locus: 1q32.1
UTRN Gene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Utrophin
Chromosome: CHR6: 144612872 -145174170
Locus: 6q24.2
Gene Diseases
The CHI3L1 UTRN Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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