CHI3L1-CBS Fusion FISH Probe
The CHI3L1-CBS Fusion FISH Probe is used to confirm a fusion of the CHI3L1 and CBS genes. The fusion of the CHI3L1 and CBS genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHI3L1-CBS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-RERE | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-REOR | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-REGO | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-REGR | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-REAQ | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-ORRE | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-OROR | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-ORGO | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-GORE | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-GOOR | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-GOGO | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-GOGR | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-GRRE | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-GROR | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-GRGO | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-GRGR | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-AQRE | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-AQOR | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-AQGO | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-AQGR | 20 (40 μL) | 200 μL |
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| CHI3L1-CBS-20-AQAQ | 20 (40 μL) | 200 μL |
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CBS Gene Summary
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
Gene Name: Cystathionine-beta-synthase
Chromosome: CHR21: 44473300 -44496472
Locus: 21q22.3
CHI3L1 Gene Summary
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]
Gene Name: Chitinase 3 Like 1
Chromosome: CHR1: 203148058 -203155922
Locus: 1q32.1
Gene Diseases
The CHI3L1 CBS Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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