CHEK1-EXOC6 Fusion FISH Probe
The CHEK1-EXOC6 Fusion FISH Probe is used to confirm a fusion of the CHEK1 and EXOC6 genes. The fusion of the CHEK1 and EXOC6 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHEK1-EXOC6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-RERE | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-REOR | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-REGO | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-REGR | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-REAQ | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-ORRE | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-OROR | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-ORGO | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-GORE | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-GOOR | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-GOGO | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-GOGR | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-GRRE | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-GROR | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-GRGO | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-GRGR | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-AQRE | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-AQOR | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-AQGO | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-AQGR | 20 (40 μL) | 200 μL |
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| CHEK1-EXOC6-20-AQAQ | 20 (40 μL) | 200 μL |
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CHEK1 Gene Summary
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Checkpoint Kinase 1
Chromosome: CHR11: 125495035 -125546150
Locus: 11q24.2
EXOC6 Gene Summary
The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal-dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2. [provided by RefSeq, Jan 2016]
Gene Name: Exocyst Complex Component 6
Chromosome: CHR10: 94594469 -94819251
Locus: 10q23.33
Gene Diseases
The CHEK1 EXOC6 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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