CHD7-ASPH Fusion FISH Probe
The CHD7-ASPH Fusion FISH Probe is used to confirm a fusion of the CHD7 and ASPH genes. The fusion of the CHD7 and ASPH genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHD7-ASPH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-RERE | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-REOR | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-REGO | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-REGR | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-REAQ | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-ORRE | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-OROR | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-ORGO | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-GORE | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-GOOR | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-GOGO | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-GOGR | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-GRRE | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-GROR | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-GRGO | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-GRGR | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-AQRE | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-AQOR | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-AQGO | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-AQGR | 20 (40 μL) | 200 μL |
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| CHD7-ASPH-20-AQAQ | 20 (40 μL) | 200 μL |
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ASPH Gene Summary
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]
Gene Name: Aspartate Beta-hydroxylase
Chromosome: CHR8: 62413114 -62627199
Locus: 8q12.3
CHD7 Gene Summary
This gene encodes a protein that contains several helicase family domains. Mutations in this gene have been found in some patients with the CHARGE syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Gene Name: Chromodomain Helicase DNA Binding Protein 7
Chromosome: CHR8: 61591323 -61780586
Locus: 8q12.2
Gene Diseases
The CHD7 ASPH Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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