CHD6-SPEN Fusion FISH Probe
The CHD6-SPEN Fusion FISH Probe is used to confirm a fusion of the CHD6 and SPEN genes. The fusion of the CHD6 and SPEN genes has been associated with Thymoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHD6-SPEN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-RERE | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-REOR | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-REGO | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-REGR | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-REAQ | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-ORRE | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-OROR | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-ORGO | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-GORE | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-GOOR | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-GOGO | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-GOGR | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-GRRE | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-GROR | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-GRGO | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-GRGR | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-AQRE | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-AQOR | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-AQGO | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-AQGR | 20 (40 μL) | 200 μL |
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| CHD6-SPEN-20-AQAQ | 20 (40 μL) | 200 μL |
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SPEN Gene Summary
This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]
Gene Name: Spen Family Transcriptional Repressor
Chromosome: CHR1: 16174358 -16266950
Locus: 1p36.21-p36.13
CHD6 Gene Summary
This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. [provided by RefSeq, Jul 2013]
Gene Name: Chromodomain Helicase DNA Binding Protein 6
Chromosome: CHR20: 40031169 -40247133
Locus: 20q12
Gene Diseases
The CHD6 SPEN Fusion has been associated with the following diseases:
| Disease Name |
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| Thymoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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