CHD6-MYH7B Fusion FISH Probe
The CHD6-MYH7B Fusion FISH Probe is used to confirm a fusion of the CHD6 and MYH7B genes. The fusion of the CHD6 and MYH7B genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHD6-MYH7B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-RERE | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-REOR | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-REGO | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-REGR | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-REAQ | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-ORRE | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-OROR | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-ORGO | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-GORE | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-GOOR | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-GOGO | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-GOGR | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-GRRE | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-GROR | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-GRGO | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-GRGR | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-AQRE | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-AQOR | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-AQGO | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-AQGR | 20 (40 μL) | 200 μL |
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| CHD6-MYH7B-20-AQAQ | 20 (40 μL) | 200 μL |
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MYH7B Gene Summary
The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010]
Gene Name: Myosin Heavy Chain 7B
Chromosome: CHR20: 33543703 -33590240
Locus: 20q11.22
CHD6 Gene Summary
This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. [provided by RefSeq, Jul 2013]
Gene Name: Chromodomain Helicase DNA Binding Protein 6
Chromosome: CHR20: 40031169 -40247133
Locus: 20q12
Gene Diseases
The CHD6 MYH7B Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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