CHCHD3-MKLN1 Fusion FISH Probe
The CHCHD3-MKLN1 Fusion FISH Probe is used to confirm a fusion of the CHCHD3 and MKLN1 genes. The fusion of the CHCHD3 and MKLN1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHCHD3-MKLN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-RERE | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-REOR | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-REGO | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-REGR | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-REAQ | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-ORRE | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-OROR | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-ORGO | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-GORE | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-GOOR | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-GOGO | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-GOGR | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-GRRE | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-GROR | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-GRGO | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-GRGR | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-AQRE | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-AQOR | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-AQGO | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-AQGR | 20 (40 μL) | 200 μL |
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| CHCHD3-MKLN1-20-AQAQ | 20 (40 μL) | 200 μL |
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MKLN1 Gene Summary
Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060) (Adams et al., 1998 [PubMed 9724633]).[supplied by OMIM, Mar 2008]
Gene Name: Muskelin 1
Chromosome: CHR7: 130794854 -131181398
Locus: 7q32.3
CHCHD3 Gene Summary
The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Gene Name: Coiled-coil-helix-coiled-coil-helix Domain Containing 3
Chromosome: CHR7: 132469622 -132766828
Locus: 7q32.3-q33
Gene Diseases
The CHCHD3 MKLN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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