CGGBP1-SCN11A Fusion FISH Probe
The CGGBP1-SCN11A Fusion FISH Probe is used to confirm a fusion of the CGGBP1 and SCN11A genes. The fusion of the CGGBP1 and SCN11A genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CGGBP1-SCN11A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-RERE | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-REOR | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-REGO | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-REGR | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-REAQ | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-ORRE | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-OROR | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-ORGO | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-ORAQ | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-GORE | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-GOOR | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-GOGO | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-GOGR | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-GOAQ | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-GRRE | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-GROR | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-GRGO | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-GRGR | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-GRAQ | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-AQRE | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-AQOR | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-AQGO | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-AQGR | 20 (40 μL) | 200 μL |
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| CGGBP1-SCN11A-20-AQAQ | 20 (40 μL) | 200 μL |
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CGGBP1 Gene Summary
This gene encodes a CGG repeat-binding protein that primarily localizes to the nucleus. CGG trinucleotide repeats are implicated in many disorders as they often act as transcription- and translation-regulatory elements, can produce hairpin structures which cause DNA replication errors, and form regions prone to chromosomal breakage. CGG repeats are also targets for CpG methylation. In addition to its ability to bind CGG repeats and regulate transcription, this gene is believed to play a role in DNA damage repair and telomere protection. In vitro studies indicate this protein does not bind to methylated CpG sequences. [provided by RefSeq, Jul 2017]
Gene Name: CGG Triplet Repeat Binding Protein 1
Chromosome: CHR3: 88101099 -88199016
Locus: 3p11.1
SCN11A Gene Summary
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked membrane depolarization and is a major effector of peripheral inflammatory pain hypersensitivity. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type VII and familial episodic pain syndrome-3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]
Gene Name: Sodium Voltage-gated Channel Alpha Subunit 11
Chromosome: CHR3: 38887259 -38992052
Locus: 3p22.2
Gene Diseases
The CGGBP1 SCN11A Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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