CGGBP1-MITF Fusion FISH Probe
The CGGBP1-MITF Fusion FISH Probe is used to confirm a fusion of the CGGBP1 and MITF genes. The fusion of the CGGBP1 and MITF genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CGGBP1-MITF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-RERE | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-REOR | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-REGO | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-REGR | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-REAQ | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-ORRE | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-OROR | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-ORGO | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-ORAQ | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-GORE | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-GOOR | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-GOGO | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-GOGR | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-GOAQ | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-GRRE | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-GROR | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-GRGO | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-GRGR | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-GRAQ | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-AQRE | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-AQOR | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-AQGO | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-AQGR | 20 (40 μL) | 200 μL |
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| CGGBP1-MITF-20-AQAQ | 20 (40 μL) | 200 μL |
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MITF Gene Summary
The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. [provided by RefSeq, Aug 2017]
Gene Name: Melanogenesis Associated Transcription Factor
Chromosome: CHR3: 69788585 -70017488
Locus: 3p13
CGGBP1 Gene Summary
This gene encodes a CGG repeat-binding protein that primarily localizes to the nucleus. CGG trinucleotide repeats are implicated in many disorders as they often act as transcription- and translation-regulatory elements, can produce hairpin structures which cause DNA replication errors, and form regions prone to chromosomal breakage. CGG repeats are also targets for CpG methylation. In addition to its ability to bind CGG repeats and regulate transcription, this gene is believed to play a role in DNA damage repair and telomere protection. In vitro studies indicate this protein does not bind to methylated CpG sequences. [provided by RefSeq, Jul 2017]
Gene Name: CGG Triplet Repeat Binding Protein 1
Chromosome: CHR3: 88101099 -88199016
Locus: 3p11.1
Gene Diseases
The CGGBP1 MITF Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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