CFTR-WNT2 Fusion FISH Probe
The CFTR-WNT2 Fusion FISH Probe is used to confirm a fusion of the CFTR and WNT2 genes. The fusion of the CFTR and WNT2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CFTR-WNT2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-RERE | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-REOR | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-REGO | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-REGR | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-REAQ | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-ORRE | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-OROR | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-ORGO | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-GORE | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-GOOR | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-GOGO | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-GOGR | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-GRRE | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-GROR | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-GRGO | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-GRGR | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-AQRE | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-AQOR | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-AQGO | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-AQGR | 20 (40 μL) | 200 μL |
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| CFTR-WNT2-20-AQAQ | 20 (40 μL) | 200 μL |
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CFTR Gene Summary
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome. [provided by RefSeq, Aug 2017]
Gene Name: Cystic Fibrosis Transmembrane Conductance Regulator
Chromosome: CHR7: 117120016 -117308718
Locus: 7q31.2
WNT2 Gene Summary
This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Wnt Family Member 2
Chromosome: CHR7: 116916685 -116963343
Locus: 7q31.2
Gene Diseases
The CFTR WNT2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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