CFLAR-NDUFB3 Fusion FISH Probe
The CFLAR-NDUFB3 Fusion FISH Probe is used to confirm a fusion of the CFLAR and NDUFB3 genes. The fusion of the CFLAR and NDUFB3 genes has been associated with Uterine Carcinosarcoma, Head And Neck Squamous Cell Carcinoma , and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CFLAR-NDUFB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-RERE | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-REOR | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-REGO | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-REGR | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-REAQ | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-ORRE | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-OROR | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-ORGO | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-GORE | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-GOOR | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-GOGO | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-GOGR | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-GRRE | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-GROR | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-GRGO | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-GRGR | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-AQRE | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-AQOR | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-AQGO | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-AQGR | 20 (40 μL) | 200 μL |
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| CFLAR-NDUFB3-20-AQAQ | 20 (40 μL) | 200 μL |
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NDUFB3 Gene Summary
This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which is the first enzyme in the electron transport chain of mitochondria. This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. Mutations in this gene contribute to mitochondrial complex 1 deficiency. Alternative splicing results in multiple transcript variants encoding the same protein. Humans have multiple pseudogenes of this gene. [provided by RefSeq, Mar 2012]
Gene Name: NADH:ubiquinone Oxidoreductase Subunit B3
Chromosome: CHR2: 201936461 -201950473
Locus: 2q33.1
CFLAR Gene Summary
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Gene Name: CASP8 And FADD Like Apoptosis Regulator
Chromosome: CHR2: 201980876 -202037411
Locus: 2q33.1
Gene Diseases
The CFLAR NDUFB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
| Head And Neck Squamous Cell Carcinoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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