CFLAR-AGBL5 Fusion FISH Probe
The CFLAR-AGBL5 Fusion FISH Probe is used to confirm a fusion of the CFLAR and AGBL5 genes. The fusion of the CFLAR and AGBL5 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CFLAR-AGBL5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-RERE | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-REOR | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-REGO | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-REGR | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-REAQ | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-ORRE | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-OROR | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-ORGO | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-ORAQ | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-GORE | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-GOOR | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-GOGO | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-GOGR | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-GOAQ | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-GRRE | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-GROR | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-GRGO | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-GRGR | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-GRAQ | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-AQRE | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-AQOR | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-AQGO | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-AQGR | 20 (40 μL) | 200 μL |
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| CFLAR-AGBL5-20-AQAQ | 20 (40 μL) | 200 μL |
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CFLAR Gene Summary
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Gene Name: CASP8 And FADD Like Apoptosis Regulator
Chromosome: CHR2: 201980876 -202037411
Locus: 2q33.1
AGBL5 Gene Summary
This gene encodes a metallocarboxypeptidase involved in protein deglutamylation and a member of the peptidase M14 family of proteins. The encoded protein has been described as a "dual-functional" deglutamylase that can remove glutamate residues from both carboxyl termini and side chains of protein substrates. This deglutamylase activity may be important in antiviral immunity. Mutations in this gene are associated with retinitis pigmentosa. [provided by RefSeq, Jul 2016]
Gene Name: ATP/GTP Binding Protein Like 5
Chromosome: CHR2: 27274490 -27293490
Locus: 2p23.3
Gene Diseases
The CFLAR AGBL5 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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