CFB-STAT6 Fusion FISH Probe
The CFB-STAT6 Fusion FISH Probe is used to confirm a fusion of the CFB and STAT6 genes. The fusion of the CFB and STAT6 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CFB-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-RERE | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-REOR | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-REGO | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-REGR | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-OROR | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-GORE | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-GROR | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| CFB-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
|
CFB Gene Summary
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
Gene Name: Complement Factor B
Chromosome: CHR6_dbb_hap3: 3199308 -3205449
Locus: 6p21.33
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The CFB STAT6 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|