CFB-SERPINA1 Fusion FISH Probe
The CFB-SERPINA1 Fusion FISH Probe is used to confirm a fusion of the CFB and SERPINA1 genes. The fusion of the CFB and SERPINA1 genes has been associated with Liver Hepatocellular Carcinoma, Liver Hepatocellular Carcinoma, Liver Hepatocellular Carcinoma, Liver Hepatocellular Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CFB-SERPINA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-RERE | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-REOR | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-REGO | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-REGR | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-REAQ | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-ORRE | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-OROR | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-ORGO | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-GORE | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-GOOR | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-GOGO | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-GOGR | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-GRRE | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-GROR | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-GRGO | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-GRGR | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-AQRE | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-AQOR | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-AQGO | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-AQGR | 20 (40 μL) | 200 μL |
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| CFB-SERPINA1-20-AQAQ | 20 (40 μL) | 200 μL |
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CFB Gene Summary
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
Gene Name: Complement Factor B
Chromosome: CHR6_dbb_hap3: 3199308 -3205449
Locus: 6p21.33
SERPINA1 Gene Summary
The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Serpin Family A Member 1
Chromosome: CHR14: 94843083 -94857029
Locus: 14q32.13
Gene Diseases
The CFB SERPINA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
| Liver Hepatocellular Carcinoma |
| Liver Hepatocellular Carcinoma |
| Liver Hepatocellular Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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