CFB-NDUFV1 Fusion FISH Probe
The CFB-NDUFV1 Fusion FISH Probe is used to confirm a fusion of the CFB and NDUFV1 genes. The fusion of the CFB and NDUFV1 genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CFB-NDUFV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-RERE | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-REOR | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-REGO | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-REGR | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-REAQ | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-ORRE | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-OROR | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-ORGO | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-GORE | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-GOOR | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-GOGO | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-GOGR | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-GRRE | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-GROR | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-GRGO | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-GRGR | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-AQRE | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-AQOR | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-AQGO | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-AQGR | 20 (40 μL) | 200 μL |
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| CFB-NDUFV1-20-AQAQ | 20 (40 μL) | 200 μL |
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CFB Gene Summary
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
Gene Name: Complement Factor B
Chromosome: CHR6_dbb_hap3: 3199308 -3205449
Locus: 6p21.33
NDUFV1 Gene Summary
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Name: NADH:ubiquinone Oxidoreductase Core Subunit V1
Chromosome: CHR11: 67374322 -67380012
Locus: 11q13.2
Gene Diseases
The CFB NDUFV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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