CEP290-VEZT Fusion FISH Probe
The CEP290-VEZT Fusion FISH Probe is used to confirm a fusion of the CEP290 and VEZT genes. The fusion of the CEP290 and VEZT genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CEP290-VEZT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-RERE | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-REOR | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-REGO | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-REGR | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-REAQ | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-ORRE | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-OROR | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-ORGO | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-ORAQ | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-GORE | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-GOOR | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-GOGO | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-GOGR | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-GOAQ | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-GRRE | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-GROR | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-GRGO | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-GRGR | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-GRAQ | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-AQRE | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-AQOR | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-AQGO | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-AQGR | 20 (40 μL) | 200 μL |
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| CEP290-VEZT-20-AQAQ | 20 (40 μL) | 200 μL |
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VEZT Gene Summary
This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Gene Name: Vezatin, Adherens Junctions Transmembrane Protein
Chromosome: CHR12: 95611521 -95696566
Locus: 12q22
CEP290 Gene Summary
This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer. [provided by RefSeq, Jul 2008]
Gene Name: Centrosomal Protein 290
Chromosome: CHR12: 88442789 -88535993
Locus: 12q21.32
Gene Diseases
The CEP290 VEZT Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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