CEP170-AKT3 Fusion FISH Probe
The CEP170-AKT3 Fusion FISH Probe is used to confirm a fusion of the CEP170 and AKT3 genes. The fusion of the CEP170 and AKT3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CEP170-AKT3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-RERE | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-REOR | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-REGO | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-REGR | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-REAQ | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-ORRE | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-OROR | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-ORGO | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-GORE | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-GOOR | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-GOGO | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-GOGR | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-GRRE | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-GROR | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-GRGO | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-GRGR | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-AQRE | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-AQOR | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-AQGO | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-AQGR | 20 (40 μL) | 200 μL |
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| CEP170-AKT3-20-AQAQ | 20 (40 μL) | 200 μL |
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CEP170 Gene Summary
The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Centrosomal Protein 170
Chromosome: CHR1: 243287729 -243418708
Locus: 1q43
AKT3 Gene Summary
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: AKT Serine/threonine Kinase 3
Chromosome: CHR1: 243651534 -244006584
Locus: 1q43-q44
Gene Diseases
The CEP170 AKT3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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