CENPM-AGR3 Fusion FISH Probe
The CENPM-AGR3 Fusion FISH Probe is used to confirm a fusion of the CENPM and AGR3 genes. The fusion of the CENPM and AGR3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CENPM-AGR3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-RERE | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-REOR | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-REGO | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-REGR | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-REAQ | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-ORRE | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-OROR | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-ORGO | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-GORE | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-GOOR | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-GOGO | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-GOGR | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-GRRE | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-GROR | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-GRGO | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-GRGR | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-AQRE | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-AQOR | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-AQGO | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-AQGR | 20 (40 μL) | 200 μL |
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| CENPM-AGR3-20-AQAQ | 20 (40 μL) | 200 μL |
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CENPM Gene Summary
The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Gene Name: Centromere Protein M
Chromosome: CHR22: 42334740 -42343148
Locus: 22q13.2
AGR3 Gene Summary
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over-expressed in breast, ovarian, and prostrate cancers. [provided by RefSeq, Dec 2016]
Gene Name: Anterior Gradient 3, Protein Disulphide Isomerase Family Member
Chromosome: CHR7: 16899029 -16921613
Locus: 7p21.1
Gene Diseases
The CENPM AGR3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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