CELSR2-FAR1 Fusion FISH Probe
The CELSR2-FAR1 Fusion FISH Probe is used to confirm a fusion of the CELSR2 and FAR1 genes. The fusion of the CELSR2 and FAR1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CELSR2-FAR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-RERE | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-REOR | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-REGO | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-REGR | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-REAQ | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-ORRE | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-OROR | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-ORGO | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-GORE | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-GOOR | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-GOGO | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-GOGR | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-GRRE | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-GROR | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-GRGO | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-GRGR | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-AQRE | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-AQOR | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-AQGO | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-AQGR | 20 (40 μL) | 200 μL |
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| CELSR2-FAR1-20-AQAQ | 20 (40 μL) | 200 μL |
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CELSR2 Gene Summary
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Cadherin EGF LAG Seven-pass G-type Receptor 2
Chromosome: CHR1: 109792640 -109818378
Locus: 1p13.3
FAR1 Gene Summary
The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]
Gene Name: Fatty Acyl-CoA Reductase 1
Chromosome: CHR11: 13690205 -13753893
Locus: 11p15.3
Gene Diseases
The CELSR2 FAR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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