CELSR1-TRMU Fusion FISH Probe
The CELSR1-TRMU Fusion FISH Probe is used to confirm a fusion of the CELSR1 and TRMU genes. The fusion of the CELSR1 and TRMU genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CELSR1-TRMU-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-RERE | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-REOR | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-REGO | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-REGR | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-REAQ | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-ORRE | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-OROR | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-ORGO | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-ORAQ | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-GORE | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-GOOR | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-GOGO | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-GOGR | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-GOAQ | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-GRRE | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-GROR | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-GRGO | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-GRGR | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-GRAQ | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-AQRE | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-AQOR | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-AQGO | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-AQGR | 20 (40 μL) | 200 μL |
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| CELSR1-TRMU-20-AQAQ | 20 (40 μL) | 200 μL |
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CELSR1 Gene Summary
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008]
Gene Name: Cadherin EGF LAG Seven-pass G-type Receptor 1
Chromosome: CHR22: 46756730 -46933067
Locus: 22q13.31
TRMU Gene Summary
This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: TRNA 5-methylaminomethyl-2-thiouridylate Methyltransferase
Chromosome: CHR22: 46731297 -46753237
Locus: 22q13.31
Gene Diseases
The CELSR1 TRMU Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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