CELSR1-CERK Fusion FISH Probe
The CELSR1-CERK Fusion FISH Probe is used to confirm a fusion of the CELSR1 and CERK genes. The fusion of the CELSR1 and CERK genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CELSR1-CERK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-RERE | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-REOR | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-REGO | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-REGR | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-REAQ | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-ORRE | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-OROR | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-ORGO | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-ORAQ | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-GORE | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-GOOR | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-GOGO | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-GOGR | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-GOAQ | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-GRRE | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-GROR | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-GRGO | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-GRGR | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-GRAQ | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-AQRE | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-AQOR | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-AQGO | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-AQGR | 20 (40 μL) | 200 μL |
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| CELSR1-CERK-20-AQAQ | 20 (40 μL) | 200 μL |
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CELSR1 Gene Summary
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008]
Gene Name: Cadherin EGF LAG Seven-pass G-type Receptor 1
Chromosome: CHR22: 46756730 -46933067
Locus: 22q13.31
CERK Gene Summary
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
Gene Name: Ceramide Kinase
Chromosome: CHR22: 47080306 -47134152
Locus: 22q13.31
Gene Diseases
The CELSR1 CERK Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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