CELF1-MYOM1 Fusion FISH Probe
The CELF1-MYOM1 Fusion FISH Probe is used to confirm a fusion of the CELF1 and MYOM1 genes. The fusion of the CELF1 and MYOM1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CELF1-MYOM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-RERE | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-REOR | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-REGO | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-REGR | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-REAQ | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-ORRE | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-OROR | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-ORGO | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-GORE | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-GOOR | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-GOGO | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-GOGR | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-GRRE | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-GROR | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-GRGO | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-GRGR | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-AQRE | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-AQOR | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-AQGO | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-AQGR | 20 (40 μL) | 200 μL |
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| CELF1-MYOM1-20-AQAQ | 20 (40 μL) | 200 μL |
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MYOM1 Gene Summary
The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Myomesin 1
Chromosome: CHR18: 3066804 -3220106
Locus: 18p11.31
CELF1 Gene Summary
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: CUGBP Elav-like Family Member 1
Chromosome: CHR11: 47487488 -47574792
Locus: 11p11.2
Gene Diseases
The CELF1 MYOM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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