CELF1-MTCH2 Fusion FISH Probe
The CELF1-MTCH2 Fusion FISH Probe is used to confirm a fusion of the CELF1 and MTCH2 genes. The fusion of the CELF1 and MTCH2 genes has been associated with Lung Squamous Cell Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CELF1-MTCH2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-RERE | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-REOR | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-REGO | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-REGR | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-REAQ | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-ORRE | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-OROR | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-ORGO | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-GORE | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-GOOR | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-GOGO | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-GOGR | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-GRRE | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-GROR | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-GRGO | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-GRGR | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-AQRE | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-AQOR | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-AQGO | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-AQGR | 20 (40 μL) | 200 μL |
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| CELF1-MTCH2-20-AQAQ | 20 (40 μL) | 200 μL |
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CELF1 Gene Summary
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: CUGBP Elav-like Family Member 1
Chromosome: CHR11: 47487488 -47574792
Locus: 11p11.2
MTCH2 Gene Summary
This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]
Gene Name: Mitochondrial Carrier 2
Chromosome: CHR11: 47638857 -47664206
Locus: 11p11.2
Gene Diseases
The CELF1 MTCH2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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