CELF1-FNBP4 Fusion FISH Probe
The CELF1-FNBP4 Fusion FISH Probe is used to confirm a fusion of the CELF1 and FNBP4 genes. The fusion of the CELF1 and FNBP4 genes has been associated with Uterine Corpus Endometrial Carcinoma, Uterine Carcinosarcoma, and Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CELF1-FNBP4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-RERE | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-REOR | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-REGO | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-REGR | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-REAQ | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-ORRE | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-OROR | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-ORGO | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-ORAQ | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-GORE | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-GOOR | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-GOGO | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-GOGR | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-GOAQ | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-GRRE | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-GROR | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-GRGO | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-GRGR | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-GRAQ | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-AQRE | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-AQOR | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-AQGO | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-AQGR | 20 (40 μL) | 200 μL |
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| CELF1-FNBP4-20-AQAQ | 20 (40 μL) | 200 μL |
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CELF1 Gene Summary
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: CUGBP Elav-like Family Member 1
Chromosome: CHR11: 47487488 -47574792
Locus: 11p11.2
FNBP4 Gene Summary
This gene encodes a protein containing two tryptophan-rich WW domains that binds the proline-rich formin homology 1 domains of formin family proteins, suggesting a role in the regulation of cytoskeletal dynamics during cell division and migration. It also binds intersectin family proteins suggesting a role in the maintenance of membrane curvature at sites of nascent vesicle formation. Naturally occurring mutations in this gene are associated with Waardenburg anophthalmia syndrome. [provided by RefSeq, Apr 2017]
Gene Name: Formin Binding Protein 4
Chromosome: CHR11: 47738068 -47788993
Locus: 11p11.2
Gene Diseases
The CELF1 FNBP4 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Uterine Carcinosarcoma |
| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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