CELF1-CHMP4B Fusion FISH Probe
The CELF1-CHMP4B Fusion FISH Probe is used to confirm a fusion of the CELF1 and CHMP4B genes. The fusion of the CELF1 and CHMP4B genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CELF1-CHMP4B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-RERE | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-REOR | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-REGO | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-REGR | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-REAQ | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-ORRE | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-OROR | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-ORGO | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-ORAQ | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-GORE | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-GOOR | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-GOGO | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-GOGR | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-GOAQ | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-GRRE | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-GROR | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-GRGO | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-GRGR | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-GRAQ | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-AQRE | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-AQOR | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-AQGO | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-AQGR | 20 (40 μL) | 200 μL |
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| CELF1-CHMP4B-20-AQAQ | 20 (40 μL) | 200 μL |
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CELF1 Gene Summary
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: CUGBP Elav-like Family Member 1
Chromosome: CHR11: 47487488 -47574792
Locus: 11p11.2
CHMP4B Gene Summary
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]
Gene Name: Charged Multivesicular Body Protein 4B
Chromosome: CHR20: 32399109 -32442173
Locus: 20q11.22
Gene Diseases
The CELF1 CHMP4B Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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