CDS1-UGT1A6 Fusion FISH Probe
The CDS1-UGT1A6 Fusion FISH Probe is used to confirm a fusion of the CDS1 and UGT1A6 genes. The fusion of the CDS1 and UGT1A6 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDS1-UGT1A6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-RERE | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-REOR | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-REGO | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-REGR | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-REAQ | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-ORRE | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-OROR | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-ORGO | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-GORE | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-GOOR | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-GOGO | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-GOGR | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-GRRE | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-GROR | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-GRGO | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-GRGR | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-AQRE | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-AQOR | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-AQGO | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-AQGR | 20 (40 μL) | 200 μL |
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| CDS1-UGT1A6-20-AQAQ | 20 (40 μL) | 200 μL |
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CDS1 Gene Summary
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]
Gene Name: CDP-diacylglycerol Synthase 1
Chromosome: CHR4: 85504056 -85572493
Locus: 4q21.23
UGT1A6 Gene Summary
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008]
Gene Name: UDP Glucuronosyltransferase Family 1 Member A6
Chromosome: CHR2: 234600320 -234681945
Locus: 2q37.1
Gene Diseases
The CDS1 UGT1A6 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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