CDKN2B-DGKD Fusion FISH Probe
The CDKN2B-DGKD Fusion FISH Probe is used to confirm a fusion of the CDKN2B and DGKD genes. The fusion of the CDKN2B and DGKD genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDKN2B-DGKD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-RERE | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-REOR | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-REGO | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-REGR | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-REAQ | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-ORRE | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-OROR | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-ORGO | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-GORE | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-GOOR | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-GOGO | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-GOGR | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-GRRE | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-GROR | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-GRGO | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-GRGR | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-AQRE | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-AQOR | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-AQGO | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-AQGR | 20 (40 μL) | 200 μL |
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| CDKN2B-DGKD-20-AQAQ | 20 (40 μL) | 200 μL |
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CDKN2B Gene Summary
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Cyclin Dependent Kinase Inhibitor 2B
Chromosome: CHR9: 22002901 -22009312
Locus: 9p21.3
DGKD Gene Summary
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Diacylglycerol Kinase Delta
Chromosome: CHR2: 234263152 -234380743
Locus: 2q37.1
Gene Diseases
The CDKN2B DGKD Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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