CDKL3-SIL1 Fusion FISH Probe
The CDKL3-SIL1 Fusion FISH Probe is used to confirm a fusion of the CDKL3 and SIL1 genes. The fusion of the CDKL3 and SIL1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CDKL3-SIL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| CDKL3-SIL1-20-AQAQ | 20 (40 μL) | 200 μL |
|
CDKL3 Gene Summary
The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Cyclin Dependent Kinase Like 3
Chromosome: CHR5: 133634114 -133702765
Locus: 5q31.1
SIL1 Gene Summary
This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: SIL1 Nucleotide Exchange Factor
Chromosome: CHR5: 138282409 -138534065
Locus: 5q31.2
Gene Diseases
The CDKL3 SIL1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|