CDKL2-CXCL11 Fusion FISH Probe
The CDKL2-CXCL11 Fusion FISH Probe is used to confirm a fusion of the CDKL2 and CXCL11 genes. The fusion of the CDKL2 and CXCL11 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDKL2-CXCL11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-RERE | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-REOR | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-REGO | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-REGR | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-REAQ | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-ORRE | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-OROR | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-ORGO | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-GORE | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-GOOR | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-GOGO | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-GOGR | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-GRRE | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-GROR | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-GRGO | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-GRGR | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-AQRE | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-AQOR | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-AQGO | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-AQGR | 20 (40 μL) | 200 μL |
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| CDKL2-CXCL11-20-AQAQ | 20 (40 μL) | 200 μL |
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CXCL11 Gene Summary
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
Gene Name: C-X-C Motif Chemokine Ligand 11
Chromosome: CHR4: 76954839 -76957350
Locus: 4q21.1
CDKL2 Gene Summary
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]
Gene Name: Cyclin Dependent Kinase Like 2
Chromosome: CHR4: 76501703 -76555721
Locus: 4q21.1
Gene Diseases
The CDKL2 CXCL11 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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