CDKAL1-EXOC2 Fusion FISH Probe
The CDKAL1-EXOC2 Fusion FISH Probe is used to confirm a fusion of the CDKAL1 and EXOC2 genes. The fusion of the CDKAL1 and EXOC2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDKAL1-EXOC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-RERE | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-REOR | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-REGO | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-REGR | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-REAQ | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-ORRE | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-OROR | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-ORGO | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-GORE | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-GOOR | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-GOGO | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-GOGR | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-GRRE | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-GROR | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-GRGO | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-GRGR | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-AQRE | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-AQOR | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-AQGO | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-AQGR | 20 (40 μL) | 200 μL |
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| CDKAL1-EXOC2-20-AQAQ | 20 (40 μL) | 200 μL |
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CDKAL1 Gene Summary
The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010]
Gene Name: CDK5 Regulatory Subunit Associated Protein 1 Like 1
Chromosome: CHR6: 20534687 -21232634
Locus: 6p22.3
EXOC2 Gene Summary
The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Gene Name: Exocyst Complex Component 2
Chromosome: CHR6: 485137 -693109
Locus: 6p25.3
Gene Diseases
The CDKAL1 EXOC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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