CDKAL1-CLCN4 Fusion FISH Probe
The CDKAL1-CLCN4 Fusion FISH Probe is used to confirm a fusion of the CDKAL1 and CLCN4 genes. The fusion of the CDKAL1 and CLCN4 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDKAL1-CLCN4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-RERE | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-REOR | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-REGO | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-REGR | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-REAQ | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-ORRE | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-OROR | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-ORGO | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-GORE | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-GOOR | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-GOGO | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-GOGR | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-GRRE | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-GROR | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-GRGO | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-GRGR | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-AQRE | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-AQOR | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-AQGO | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-AQGR | 20 (40 μL) | 200 μL |
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| CDKAL1-CLCN4-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN4 Gene Summary
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]
Gene Name: Chloride Voltage-gated Channel 4
Chromosome: CHRX: 10124984 -10205699
Locus: Xp22.2
CDKAL1 Gene Summary
The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010]
Gene Name: CDK5 Regulatory Subunit Associated Protein 1 Like 1
Chromosome: CHR6: 20534687 -21232634
Locus: 6p22.3
Gene Diseases
The CDKAL1 CLCN4 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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