CDK8-IKZF3 Fusion FISH Probe
The CDK8-IKZF3 Fusion FISH Probe is used to confirm a fusion of the CDK8 and IKZF3 genes. The fusion of the CDK8 and IKZF3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDK8-IKZF3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-RERE | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-REOR | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-REGO | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-REGR | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-REAQ | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-ORRE | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-OROR | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-ORGO | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-GORE | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-GOOR | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-GOGO | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-GOGR | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-GRRE | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-GROR | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-GRGO | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-GRGR | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-AQRE | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-AQOR | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-AQGO | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-AQGR | 20 (40 μL) | 200 μL |
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| CDK8-IKZF3-20-AQAQ | 20 (40 μL) | 200 μL |
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CDK8 Gene Summary
This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Gene Name: Cyclin Dependent Kinase 8
Chromosome: CHR13: 26828755 -26978569
Locus: 13q12.13
IKZF3 Gene Summary
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]
Gene Name: IKAROS Family Zinc Finger 3
Chromosome: CHR17: 37921198 -38020441
Locus: 17q12-q21.1
Gene Diseases
The CDK8 IKZF3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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