CDK6-HEPACAM2 Fusion FISH Probe
The CDK6-HEPACAM2 Fusion FISH Probe is used to confirm a fusion of the CDK6 and HEPACAM2 genes. The fusion of the CDK6 and HEPACAM2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CDK6-HEPACAM2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| CDK6-HEPACAM2-20-AQAQ | 20 (40 μL) | 200 μL |
|
CDK6 Gene Summary
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]
Gene Name: Cyclin Dependent Kinase 6
Chromosome: CHR7: 92234234 -92465941
Locus: 7q21.2
HEPACAM2 Gene Summary
This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology and apoptosis. Poly(ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients. [provided by RefSeq, Oct 2016]
Gene Name: HEPACAM Family Member 2
Chromosome: CHR7: 92817899 -92855782
Locus: 7q21.2
Gene Diseases
The CDK6 HEPACAM2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|