CDK5RAP2-ENG Fusion FISH Probe
The CDK5RAP2-ENG Fusion FISH Probe is used to confirm a fusion of the CDK5RAP2 and ENG genes. The fusion of the CDK5RAP2 and ENG genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDK5RAP2-ENG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-RERE | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-REOR | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-REGO | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-REGR | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-REAQ | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-ORRE | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-OROR | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-ORGO | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-GORE | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-GOOR | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-GOGO | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-GOGR | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-GRRE | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-GROR | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-GRGO | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-GRGR | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-AQRE | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-AQOR | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-AQGO | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-AQGR | 20 (40 μL) | 200 μL |
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| CDK5RAP2-ENG-20-AQAQ | 20 (40 μL) | 200 μL |
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ENG Gene Summary
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
Gene Name: Endoglin
Chromosome: CHR9: 130577290 -130617047
Locus: 9q34.11
CDK5RAP2 Gene Summary
This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Name: CDK5 Regulatory Subunit Associated Protein 2
Chromosome: CHR9: 123151146 -123342437
Locus: 9q33.2
Gene Diseases
The CDK5RAP2 ENG Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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