CDK2-UBE3A Fusion FISH Probe
The CDK2-UBE3A Fusion FISH Probe is used to confirm a fusion of the CDK2 and UBE3A genes. The fusion of the CDK2 and UBE3A genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDK2-UBE3A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-RERE | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-REOR | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-REGO | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-REGR | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-REAQ | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-ORRE | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-OROR | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-ORGO | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-GORE | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-GOOR | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-GOGO | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-GOGR | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-GRRE | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-GROR | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-GRGO | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-GRGR | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-AQRE | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-AQOR | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-AQGO | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-AQGR | 20 (40 μL) | 200 μL |
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| CDK2-UBE3A-20-AQAQ | 20 (40 μL) | 200 μL |
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CDK2 Gene Summary
This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Name: Cyclin Dependent Kinase 2
Chromosome: CHR12: 56360555 -56366568
Locus: 12q13.2
UBE3A Gene Summary
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Protein Ligase E3A
Chromosome: CHR15: 25582395 -25684175
Locus: 15q11.2
Gene Diseases
The CDK2 UBE3A Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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