CDK12-IKZF3 Fusion FISH Probe
The CDK12-IKZF3 Fusion FISH Probe is used to confirm a fusion of the CDK12 and IKZF3 genes. The fusion of the CDK12 and IKZF3 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDK12-IKZF3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-RERE | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-REOR | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-REGO | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-REGR | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-REAQ | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-ORRE | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-OROR | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-ORGO | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-GORE | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-GOOR | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-GOGO | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-GOGR | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-GRRE | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-GROR | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-GRGO | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-GRGR | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-AQRE | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-AQOR | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-AQGO | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-AQGR | 20 (40 μL) | 200 μL |
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| CDK12-IKZF3-20-AQAQ | 20 (40 μL) | 200 μL |
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IKZF3 Gene Summary
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]
Gene Name: IKAROS Family Zinc Finger 3
Chromosome: CHR17: 37921198 -38020441
Locus: 17q12-q21.1
CDK12 Gene Summary
The Cyclin Dependent Kinase 12 (CDK12) gene is located on chr17 :37617738-37690800 at 17q12.
Gene Name: Cyclin Dependent Kinase 12
Chromosome: CHR17: 37617738 -37690800
Locus: 17q12
Gene Diseases
The CDK12 IKZF3 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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