CDK10-SPG7 Fusion FISH Probe
The CDK10-SPG7 Fusion FISH Probe is used to confirm a fusion of the CDK10 and SPG7 genes. The fusion of the CDK10 and SPG7 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDK10-SPG7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-RERE | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-REOR | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-REGO | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-REGR | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-REAQ | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-ORRE | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-OROR | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-ORGO | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-GORE | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-GOOR | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-GOGO | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-GOGR | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-GRRE | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-GROR | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-GRGO | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-GRGR | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-AQRE | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-AQOR | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-AQGO | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-AQGR | 20 (40 μL) | 200 μL |
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| CDK10-SPG7-20-AQAQ | 20 (40 μL) | 200 μL |
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SPG7 Gene Summary
This gene encodes a mitochondrial metalloprotease protein that is a member of the AAA family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Mutations in this gene cause autosomal recessive spastic paraplegia 7. Two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2014]
Gene Name: SPG7, Paraplegin Matrix AAA Peptidase Subunit
Chromosome: CHR16: 89574804 -89624174
Locus: 16q24.3
CDK10 Gene Summary
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Name: Cyclin Dependent Kinase 10
Chromosome: CHR16: 89753075 -89762772
Locus: 16q24.3
Gene Diseases
The CDK10 SPG7 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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