CDK1-NRG1 Fusion FISH Probe
The CDK1-NRG1 Fusion FISH Probe is used to confirm a fusion of the CDK1 and NRG1 genes. The fusion of the CDK1 and NRG1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDK1-NRG1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-RERE | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-REOR | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-REGO | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-REGR | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-REAQ | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-ORRE | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-OROR | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-ORGO | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-GORE | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-GOOR | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-GOGO | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-GOGR | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-GRRE | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-GROR | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-GRGO | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-GRGR | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-AQRE | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-AQOR | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-AQGO | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-AQGR | 20 (40 μL) | 200 μL |
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| CDK1-NRG1-20-AQAQ | 20 (40 μL) | 200 μL |
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CDK1 Gene Summary
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Name: Cyclin Dependent Kinase 1
Chromosome: CHR10: 62538211 -62554610
Locus: 10q21.2
NRG1 Gene Summary
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
Gene Name: Neuregulin 1
Chromosome: CHR8: 31497267 -32600770
Locus: 8p12
Gene Diseases
The CDK1 NRG1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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