CDH17-RAD54B Fusion FISH Probe
The CDH17-RAD54B Fusion FISH Probe is used to confirm a fusion of the CDH17 and RAD54B genes. The fusion of the CDH17 and RAD54B genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDH17-RAD54B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-RERE | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-REOR | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-REGO | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-REGR | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-REAQ | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-ORRE | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-OROR | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-ORGO | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-GORE | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-GOOR | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-GOGO | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-GOGR | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-GRRE | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-GROR | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-GRGO | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-GRGR | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-AQRE | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-AQOR | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-AQGO | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-AQGR | 20 (40 μL) | 200 μL |
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| CDH17-RAD54B-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH17 Gene Summary
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Gene Name: Cadherin 17
Chromosome: CHR8: 95139393 -95229531
Locus: 8q22.1
RAD54B Gene Summary
The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008]
Gene Name: RAD54 Homolog B (S. Cerevisiae)
Chromosome: CHR8: 95384187 -95487343
Locus: 8q22.1
Gene Diseases
The CDH17 RAD54B Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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